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【力学讲堂】4月14日 Elasticity effects on the cell uptake of nanoparticles

发布时间:2017-4-7 12:05:32  点击次数:168

 

主  办:力学系与湍流重点实验室
报告人:易新 特聘研究员
时  间:4月14日 周五 中午12:00
地  点:力学楼434室
主持人:杨莹 教授


报告内容摘要:


Elastic particles including capsules, polymersomes and vesicular particles such as conventional liposomes are widely used in the fields of drug delivery. However, the mechanics of their interaction with cells are not very clear and there have been no systematic studies on the elasticity effects in cell uptake. In this talk, I will present our recent theoretical work on the interaction between elastic particles and cell membranes as well as vesicles. In particular, I will discuss how particle elasticity affect the membrane wrapping process, the kinetics of receptor-mediated endocytosis, and particle incorporation into a vesicle as well as outward budding from a vesicle. In the case of membrane wrapping, we found that soft nanoparticles are energetically less prone to full wrapping than stiff ones, but the wrapping of the former is kinetically faster than that of the latter. For the particle interaction with a vesicle, we found that soft particles are more energetically prone to full internalization into a vesicle than being released out of the vesicle.
 
 
 
报告人简介:


地址:北京大学工学院力学楼 邮政编码:100871 电话:010-62751812 传真:010-62751812 电子邮件:mes@coe.pku.edu.cn